Salpingectomy does not increase risk of ovarian cancer: JAMA

A recent study by Vasily Giannakeas and team did not observe any connection between salpingectomy and the risk of ovarian cancer. The findings were published in the Journal of American Medical Association.

This study was undertaken because a body of clinical and pathological evidence suggests that a significant portion of high-grade serous ovarian cancers originates in the fallopian tube. Consequently, salpingectomy is now being considered for permanent contraception as an alternative to tubal ligation, or for ovarian cancer prevention when performed alongside surgical procedures for benign gynecologic conditions. The primary goal of this research was to investigate the potential link between salpingectomy and the risk of invasive epithelial ovarian, fallopian tube, and peritoneal cancer.

This retrospective cohort study, based on the population, encompassed all women between the ages of 18 and 80 who were eligible for healthcare services in Ontario, Canada. Participants were identified using health-related administrative databases from Ontario, covering the period from January 1, 1992, to December 31, 2019. The study involved a total of 131,516 women who were subjected to the primary (matched) analysis. These women were monitored until December 31, 2021. The primary criteria for the study involved comparing salpingectomy (with or without hysterectomy) to no pelvic procedure (the control condition) among women in the general population.