Sarcopenia and platelet-lymphocyte ratio of prognostic value in patients of head neck cancer
Recent research has highlighted that systemic inflammation is significantly associated with sarcopenia. Also,the survival and oncological effects of sarcopenia were enhanced when platelet-lymphocyte ratio (PLR) was high. Thus, the combination of these two parameters may be useful for identifying HNC patients at a risk of poor survival outcomes,affirmed the research team. The interesting findings have been put forth in Auris Nasus Larynx.
Numerous complex mechanisms lead to sarcopenia, including neurodegeneration, impaired signaling, inflammation, disuse, and declined nutrient intake. Sarcopenia has been shown to be prevalent in adults with cancer due to the increasing prevalence of disease with age . Furthermore, inflammation and malnutrition associated with cancer may worsen muscles.Although both sarcopenia and systemic inflammation affect the outcomes of head and neck cancer (HNC) patients, the association between sarcopenia and systemic inflammation and the combined prognostic effect of these factors in HNC patients remain unknown. This recent study aimed to evaluate the effect of sarcopenia with systemic inflammation on survival and disease control in HNC patients.
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