Severity of diabetes tied to worsening of lung cancer: Study
Written By : Dr. Shravani Dali
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2022-06-17 14:30 GMT | Update On 2022-06-17 14:31 GMT
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More severe diabetes may worsen lung cancer prognosis according to a recent study published in the Cancers (Basel)
The survival impact of diabetes severity on lung cancer remains unclear. They performed head-to-head propensity score matching to estimate the survival impact of various adapted diabetes complications severity index (aDCSI) scores in patients with both diabetes and lung squamous cell carcinoma (SqCLC).
They enrolled patients with both diabetes and lung SqCLC and categorized them into the mild (aDCSI = 0-1) and moderate-to-severe (aDCSI ≥ 2) diabetes groups. The patients in both groups were matched at a 1:1 ratio.
Results:
- the matching process yielded a final cohort of 5742 patients with both diabetes and lung SqCLC (2871 patients in the mild diabetes group and 2871 patients in the moderate-to-severe diabetes groups) who were eligible for further analysis.
- A multivariate Cox regression analysis revealed that the adjusted hazard ratio (aHR; 95% confidence interval) of all-cause death for the mild diabetes group relative to the moderate-to-severe diabetes group was 1.17
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