Some cancer immunotherapies may lead to myocarditis and other potentially serious arrhythmias: Study
Immune checkpoint inhibitors (ICIs) have transformed cancer care by unleashing T-cells to fight tumors, but they can cause serious cardiotoxicities including myocarditis. ICI-induced myocarditis represents a new clinical syndrome because of the novelty and considerable usage of ICIs.
While it has been hard to fully define the clinical features of ICI-myocarditis, new research provides a clearer picture of the highly arrhythmogenic nature of myocarditis brought about by these inhibitors.
In a study headed by UC San Francisco researchers and published in Circulation this week, the investigators report electrocardiographic and arrhythmogenic features of ICI-myocarditis. The group utilized an online platform to establish an international registry from 49 institutions and 11 countries of ICI-myocarditis. While close to 500 cases have been collected, 125 patients with electrocardiograms at the time of hospitalization were identified. Two cardiologists analyzed the electrocardiograms while blinded to the individual case and outcome.
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.055816
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