Study finds O+ blood group to be more prevalent with gynecological cancers

The study comprised a total of 543 female patients in total with the average age being 61.6. In the GC instances, O+ (43.8%), A+ (26%), and B+ (15.5%) were the 3 most prevalent blood groups. The 3 most common comorbidities which impacted the GC patients were dyslipidemia, diabetes mellitus, and hypertension (HTN). ABO BG was shown to be significantly (p < 0.05) associated with serous histology in endometrial cancer.

There was a strong correlation between serous histology and B blood group (p < 0.05) and ABO blood group and fallopian carcinoma. The recurrence rates for ovarian cancer were found to be significantly correlated with the AB blood group (p < 0.05). In the instance of patient-dependent GCs, there was a significant correlation (P<0.05) between mixed GCs and tumor type (carcinoma), vaginal/vulval cancers and TNM stage, ovarian cancers and recurrence, and fallopian tube cancers and adverse events and survival status.

Also, the risk of cervical, endometrial, and ovarian malignancies was determined to be substantial for Type B BG (P < 0.05) based on multinomial analysis between GCs and other confounding factors. Overall, this study showed that the most prevalent blood type in this population was Type O + BG. Additionally, vaginal/valval cancer was the most prevalent cancer among our patients and the rarest.

Source:

Aga, S. S., Khan, M. A., Al Mansour, M., Hasosah, R. M., Alsubaie, L. A., Alfaify, D. A., Alansari, M. B., Almutairi, S. O., & Nissar, S. (2025). Association of blood group types and clinico-pathological features of gynecological cancers (GCs). BMC Cancer, 25(1). https://doi.org/10.1186/s12885-025-13527-z