Treatment of H. pylori infection may reduce risk of colorectal cancer and associated mortality: Study
Written By : Aditi
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2024-03-06 20:15 GMT | Update On 2024-03-07 04:53 GMT
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Although H. pylori infection does not itself cause illness but, chronic infection is associated with long-lasting inflammation in the stomach, which can cause complications like atrophic gastritis and stomach cancer.
According to a study published in the Journal of Clinical Oncology, H. pylori-positive individuals may exhibit a small yet statistically significant increase in the incidence and mortality rates of colorectal cancer (CRC). Untreated individuals, especially those with active infections, seem at the most significant risk.
Helicobacter pylori is the most common cause of infection-associated cancer worldwide. This study evaluated the impact of H. pylori infection and treatment on CRC incidence and mortality.
The study included patients in the US who completed H. pylori testing between 1999 and 2018. They conducted a retrospective cohort analysis among adults within the Veterans Health Administration who completed testing for H. pylori. The primary exposures were H. pylori test results (positive/negative) and treatment (untreated/treated) among H. pylori-positive individuals. The primary outcomes were CRC incidence and mortality. Follow-up started at the first H. pylori testing and continued until the earliest incident or fatal CRC, non-CRC death, or December 31, 2019.
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