Vitamin D insufficiency tied to increased incidence of cutaneous melanoma
USA: Findings from a meta-analysis suggest the importance of identifying vitamin D insufficiency for evaluating and treating patients at a higher risk of developing cutaneous melanoma (CM).
The researchers, in their study published in Melanoma Research, identified an association between increased incidence of cutaneous melanoma and vitamin D insufficiency. They also observed less favourable Breslow tumour depth with lower vitamin D levels and the presence of vitamin D insufficiency.
The study showed that a vitamin D level <20 ng/dL was linked with an increased incidence of cutaneous melanoma (RR, 1.45). A vitamin D level >20 ng/dL was correlated with Breslow depth <1 mm and a lower vitamin D level was associated with Breslow depth >1 mm.
Cutaneous melanoma is the deadliest skin cancer, and vitamin D insufficiency has been indicated as a risk factor. Richard A Shellenberger, Trinity Health Ann Arbor Hospital, Ann Arbor, Michigan, and colleagues sought to explore the relationship between both vitamin D insufficiency and 25-hydroxy vitamin D levels with the incidence and stage of CM in a systematic review and meta-analysis.
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