Will higher Selenium status prevent Cancer risk?
According to a new study, having a high selenium level may not prevent the development of cancer. The links between kidney cancer and multiple myeloma must be confirmed in well-powered investigations.
As the evidence for a link between selenium and cancer risk is ambiguous, this study was conducted by Shuai Yuan and team with the objective to investigate the links between selenium levels and 22 different types of cancer, as well as any cancer.
The findings of this study were published in the International Journal of Cancer on 15 December, 2021.
For this study, as instrumental variables, single nucleotide polymorphisms highly related with toenail and blood (TAB) and blood selenium levels in mild linkage disequilibrium (r2 0.3) were utilized. The UK Biobank was used to obtain genetic correlations of selenium-associated single nucleotide polymorphisms with cancer, which included 59,647 cancer cases and 307,914 controls. Associations with p0.1 in the UK Biobank were evaluated for replication in the FinnGen collaboration, which included over 180,000 people. The relationships were estimated using the inverse-variance weighted technique, which accounts for linkage disequilibrium.
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