Diagnostic challenges in diabetic retinopathy: IJO Case Report

(b). The deep capillary plexus (DCP) also showed the right-angled venule with telangiectatic vessels in the perifoveal region

(c). The outer retina to choriocapillaris (ORCC) slab showed distinct subretinal neovascularization.

(e) OCT of the right eye one month after aflibercept injection showed a reduction in the intraretinal fluid and a decrease in the outer retinal hyper-reflectivity. There was mild atrophy of the retinal layers suggestive of macular telangiectasia.

Diagnosis: The diagnosis was moderate NPDR with type 2 macular telangiectasia (MacTel) stage 5 in OD. Management The patient was advised therapy with intravitreal injections of anti‑VEGF (aflibercept 2 mg/0.1 ml) for the subretinal neovascularization and intraretinal fluid. The patient experienced subjective improvement of vision (improved to 20/70 from 20/100 in OD). There was decrease in the intraretinal fluid at 1 month after the injection.

MacTel is characterized by telangiectatic retinal vessels with retinal thinning, atrophy of the Muller cells, and progressive photoreceptor damage. The pathological changes in MacTel begin juxtafoveally and can be complicated by the development of subretinal neovascularization, leading to severely decreased vision. There is an overall higher incidence of type 2 MacTel in patients with diabetes mellitus. In addition, certain histopathological changes are common between the two entities.The occurrence of subretinal neovascularization in MacTel along with NPDR is very rare (less than 3% cases). Therefore, these patients require meticulous retinal imaging when subretinal neovascularization is suspected. This case by Aniruddha Agarwal highlights the importance of OCT and OCTA in establishing the accurate diagnosis and initiating therapy in the patient.

Source: Agarwal A. Co-existing retinal pathologies: Diagnostic challenges in diabetic retinopathy. Indian J Ophthalmol 2021;69:2931.