Calcium Channel Blocker Use Linked to Increased Glaucoma Risk

The study found that the use of calcium channel blockers was linked to thinner inner retinal layer thicknesses, as measured by macular ganglion cell-inner plexiform layer (mGCIPL) and macular retinal nerve fiber layer (mRNFL) thicknesses. The decrease in thickness was approximately 0.34 μm (CI: -0.54 to -0.15 μm; p = 0.001) for mGCIPL and 0.16 μm (CI: -0.30 to -0.02 μm; p = 0.03) for mRNFL.

There was no statistically significant association between the use of calcium channel blockers and intraocular pressure (IOP), with a negligible change of -0.01 mm Hg (CI: -0.09 to 0.07 mm Hg; p = 0.84).

These comprehensive findings underscore a concerning association between CCB usage and glaucoma, along with related structural changes in the inner retinal layers. Importantly, it suggests that this relationship might not be mediated by changes in intraocular pressure, raising the possibility of other mechanisms at play. Although a causal link has yet to be established, these results emphasize the need for further investigation and consideration when prescribing CCBs, especially in patients at risk of glaucoma. Regular eye examinations are crucial for individuals taking CCBs to monitor their eye health and detect potential issues promptly.

Reference:

Kastner, A., Stuart, K. V., Montesano, G., De Moraes, C. G., Kang, J. H., Wiggs, J. L., Pasquale, L. R., Hysi, P., Chua, S. Y. L., Patel, P. J., Foster, P. J., Khaw, P. T., Khawaja, A. P., Allen, N., Aslam, T., Atan, D., Balaskas, K., Barman, S., Barrett, J., … UK Biobank Eye and Vision Consortium. (2023). Calcium channel blocker use and associated glaucoma and related traits among UK Biobank participants. JAMA Ophthalmology. https://doi.org/10.1001/jamaophthalmol.2023.3877