Could Magnetic Cell Delivery Transform Future of Cornea Transplant Surgery?

Corneal edema or swelling is one of the most common reasons people need a corneal transplant. It happens when the cells that line the inner-most layer of the cornea, endothelial cells, decrease in number, causing the cornea to swell and lose clarity. Typically, the only option to restore vision is corneal transplantation surgery. But researchers are working on a novel way to simply replace the missing cells with an injection of donor cells. After loading the donor cells up with superparamagnetic nanoparticles, they are injected into the front of the eye. A magnetic eye patch is then placed in front of the eye and the patient lies face down. The magnet draws the cells to the correct location, where they remain and integrate. The first 21 patients treated this way experienced improved vision. The study will be presented today at AAO 2023, the 127th annual meeting of the American Academy of Ophthalmology.
“To our knowledge, we are the first group to show that injection of endothelial cells without surgical intervention can improve vision in subjects with Fuchs endothelial corneal dystrophy,” said Ellen Koo, MD, lead researcher and associate professor at the Bascom Palmer Eye Institute, University of Miami. “We are excited for the future.”
All 21 subjects had corneal edema due to Fuchs endothelial corneal dystrophy. Some underwent endothelium removal (descemetorhexis) before the cells were injected intracamerally, and some did not. They were treated at six centers across the US. Four doses (50,000, 150,000, 500,000, one million cells) were tested. The primary outcome was safety. At six months follow-up, there were no product-related adverse events. Pressure inside the eye remained stable, and no inflammation was observed. There was a dose-dependent continued improvement in vision up to 6 months after injection, with no patients requiring surgery.
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