Decreased oxygen delivery to retinal tissue increases retinopathy risk in young T1D patients: Study

Decreased delivery of oxygen to retinal tissue tied with occurrence non-proliferative diabetic retinopathy (NPDR) in young type-1 diabetes mellitus (DM1) patients, according to a recent study published in the Acta Ophthalmologica.
Diabetic retinopathy (DR) is a vision-threatening disease characterized by hypoxia, vascular alterations and oedema. Oxygen (O2) metabolism is involved in the development of Diabetic retinopathy. New discoveries in retinal O2 metabolism and vascular changes are essential to better understand the pathophysiology of DR. The O2 saturation in larger retinal vessels is a marker of retinal metabolism and vascular function.
A group of researchers conducted a study to determine the contribution of retinal vessel density (VD), central retinal vessel diameter and retinal oxygen (O2) saturation independently of other known risk factors in the development of non-proliferative diabetic retinopathy (NPDR).
Macular optical coherence tomography angiography (OCTA), central retinal artery/vein equivalent diameter (CRAE/CRVE) measurements and retinal oximetry were performed in a cross-sectional study of 166 eyes from 166 individuals with type 1 diabetes (T1D) aged 14–30 years. Multiple logistic regression analysis was used to investigate whether O2 saturation, retinal vessel diameters and vessel density in the deep capillary plexus (VD-DCP) were associated with NPDR, when adjusting for known risk factors. The individuals were allocated to one group without and one group with NPDR.
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