Fluoxetine may improve visual field defects among patients with stroke-related vision loss

Results:

Intention-to-treat analysis of the primary end point, percent improvement in perimetric mean deviation, showed a nonsignificant benefit of fluoxetine (64.4%, n = 5) compared with placebo (26.0%, n = 7, one-tailed 95% confidence interval (CI) = (−2.13, ∞), P = 0.06). The original blind field completely recovered in 60% receiving fluoxetine and 14% receiving placebo (odds ratio = 7.22, one-tailed 95% CI = (0.50, ∞)).

These results suggest a trend in favor of fluoxetine for vision recovery after stroke and have the potential to inform the design of a larger multicenter trial.

Reference:

Schneider, Colleen L. PhD; Prentiss, Emily K. BS; Busza, Ania MD, PhD; Williams, Zoë R. MD; Mahon, Bradford Z. PhD; Sahin, Bogachan MD, PhD. FLUORESCE: A Pilot Randomized Clinical Trial of Fluoxetine for Vision Recovery After Acute Ischemic Stroke. Journal of Neuro-Ophthalmology 43(2):p 237-242, June 2023. | DOI: 10.1097/WNO.0000000000001654

Keywords:

Fluoxetine, may, improve, visual field, defects, among, patients, stroke-related, vision loss,Journal of Neuro-Ophthalmology, Schneider, Colleen L. PhD; Prentiss, Emily K. BS; Busza, Ania MD, PhD; Williams, Zoë R. MD; Mahon, Bradford Z. PhD; Sahin, Bogachan