Galactomannan Testing Effective in Diagnosing Aspergillus Endophthalmitis, finds study

This study employed receiver operating characteristic (ROC) curves to evaluate the diagnostic significance of the galactomannan test. The area under the ROC curve for AE was a perfect 1.00 by indicating an exceptional ability of the test to differentiate between AE and other conditions. At a cutoff ODI of 1.88, the galactomannan test achieved a sensitivity and specificity of 100% by which it correctly identified all cases of AE without any false positives.

These findings are particularly important for clinical practice, where rapid and accurate diagnosis of AE is crucial for preventing severe vision loss. The high sensitivity and specificity of galactomannan testing suggest that it could become a potential diagnostic tool by offering ophthalmologist a faster way to initiate appropriate antifungal treatment. Overall, the outcomes of this study suggest that galactomannan testing of intraocular fluid promises high diagnostic accuracy and also stands out as a rapid and reliable modality for the diagnosis of Aspergillus endophthalmitis. 

Source:

Yu, T., Chen, L., Qian, Z., & Tao, Y. (2024). EXAMINATION OF GALACTOMANNAN LEVELS IN INTRAOCULAR FLUID TO ASSIST THE DIAGNOSIS OF ASPERGILLUS ENDOPHTHALMITIS. In Retina. Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1097/iae.0000000000004119