GLP-1 Receptor Agonists Linked to Lower Glaucoma Risk Compared to Metformin in Type 2 Diabetes Patients: Study
USA: A recent comparative study has uncovered promising evidence that GLP-1 receptor agonists may offer significant ocular benefits over metformin for patients with type 2 diabetes, particularly in reducing the risk of glaucoma. The findings, which highlight a potential new advantage of GLP-1 receptor agonists, could influence future treatment strategies for managing diabetes-related complications.
"GLP-1 receptor agonists are linked to a substantially reduced incidence of primary open-angle glaucoma (POAG), ocular hypertension, and the requirement for first-line glaucoma treatments compared to metformin in patients with type 2 diabetes," the researchers wrote in Ophthalmology.
Glaucoma, a leading cause of vision loss, often presents in individuals with type 2 diabetes due to various factors, including elevated intraocular pressure and poor metabolic control. Traditional treatments for diabetes primarily focus on managing blood glucose levels, with metformin being one of the most commonly prescribed medications. In the study, Iqbal Ike K Ahmed, John A. Moran Eye Center, University of Utah, Salt Lake City, USA, and colleagues compared the impact of glucagon-like peptide-1 (GLP-1) receptor agonists and metformin on the risk of primary open-angle glaucoma, ocular hypertension, and the necessity for first-line glaucoma treatments in individuals with type 2 diabetes.
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