Good Blood sugar control halts diabetic retinopathy by modifying genetic susceptibily: Study
Hong Kong: A recent study in the journal Investigative Ophthalmology & Visual Science reveals a probable interaction between blood sugar control and a single nucleotide polymorphism (SNP) on the risk of severe diabetic retinopathy (DR). The findings may help in designing effective strategies for the prevention and treatment of diabetic retinopathy (DR) -- a global leading cause of blindness.
High blood sugar plays a prominent role in a cascade of damaging molecular and cellular effects, such as oxidative stress, abnormal glycosylation, and inflammation, that may contribute to the development and severity of diabetic retinopathy.
Blood sugar control is known to be an important modifiable risk factor for diabetic retinopathy (DR). However, whether hemoglobin A1c (HbA1c) as an indicator for blood sugar control could modify genetic susceptibility to severe diabetic retinopathy (DR) needs to be investigated. Therefore this study by Kelvin K. K. Ng, Department of Medicine, The University of Hong Kong, Hong Kong, and colleagues aimed to investigate whether HbA1c could modulate the genetic susceptibility to severe diabetic retinopathy (DR) in Chinese patients with type 2 diabetes.
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