Intracanalicular Insert of Dexamethasone Effective option for Allergic Conjunctivitis

Courtesy by Eugene B. McLaurin et al., American Journal of Ophthalmology
Allergic conjunctivitis is reported in up to 40% of the general population and it is associated with a reduction in patients' quality of life. In a recent study, the researchers have found dexamethasone intracanalicular insert is well tolerated and provide relief of ocular itching for up to 4 weeks in patients with allergic conjunctivitis. The study findings were published in the American Journal of Ophthalmology on March 24, 2021.
Topical antihistamines, which competitively and reversibly block histamine receptors, are commonly used to treat allergic conjunctivitis and have a rapid onset but short duration of action, which requires multiple installations throughout the day. Corticosteroids can treat this response but, serious side effects are a concern. Because of safety issues due to side effects, both steroid-induced and preservative-induced, with long-term use, there is a continued unmet need for long-acting therapy with consistent efficacy, a reduced dosing burden, and an improved ability to inhibit the late-phase inflammatory response without inducing any serious side effects. Therefore, scientists developed intracanalicular dexamethasone insert to replace traditional corticosteroids drops. In this study, Dr Eugene B. McLaurin and his team conducted a phase 3 study to evaluate the efficacy and safety of a dexamethasone intracanalicular ocular insert for the treatment of allergic conjunctivitis.
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