Lotilaner Ophthalmic Solution Promising Treatment for Demodex Blepharitis: Study
Demodex blepharitis, caused by an infestation of Demodex mites, poses a significant burden on affected individuals, impacting their quality of life. Traditional management options have been associated with adverse effects, prompting the search for novel therapeutic alternatives. A recent systematic review and meta-analysis assessed the safety and efficacy of lotilaner ophthalmic solution (0.25%) as a treatment for Demodex blepharitis. The study was published in the American Journal Of Ophthalmology. The study was conducted by Talha M. and colleagues.
Demodex blepharitis affects millions of individuals worldwide, leading to various ocular manifestations. Prior management strategies, including topical tea tree oil and antibiotics, were associated with adverse effects. Lotilaner, an antiparasitic compound, offers a targeted approach for Demodex eradication.
The systematic review included data from four randomized controlled trials and two single-arm studies, comprising a total of 328 neonates. Studies were selected based on eligibility criteria, including treatment with lotilaner ophthalmic solution and assessment of Demodex mite eradication and collarette score.
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