Low dose naltraxone effective for neuropathic corneal pain,finds study
In a recently published study in The Ocular Surface ,researchers have highlighted that low dose naltraxone ( LDN ) is effective and well-tolerated for Neuropathic corneal pain( NCP) treatment.
Neuropathic corneal pain (NCP) is caused by damage or disease of the somatosensory nervous system that innervates the cornea and presents with symptoms of pain or persistent unpleasant sensations, such as burning, dryness, or light sensitivity.
In this retrospective study ,researchers assessed the efficacy and tolerability of low-dose naltrexone (LDN) in refractory NCP patients.
For the study design,Fifty-nine NCP patients with a centralized component treated with oral LDN 4.5 mg at bedtime for at least four weeks were identified. Thirty out of 59 patients who had a baseline pain score ≥4 on the visual analogue scale had completed the ocular pain assessment survey (OPAS) and presented persistent pain, despite instillation of topical anesthetic drops, were included. Changes in pain scores, comorbidities, side effects, among others, were analyzed. Change in ocular pain scores (scale 0-10) and quality of life (QoL) scores (scale 0-100%) were the main endpoints.
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