Methotrexate injection can rescue eyes in relapsed PIOL patients: Study
UK: Intravitreal methotrexate (MTX) is a safe and effective treatment for relapsed PIOL (primary intraocular lymphoma), according to a recent study in the British Journal of Ophthalmology. It helped in achieving local tumour control in 89% of the patients. The findings were also presented in part at the 52nd Annual Scientific Meeting of the Retina Society, London, UK, September 2019.
Mona Mohammad, Moorfields Eye Hospital NHS Foundation Trust, London, UK, and colleagues reported the outcomes of MTX injections to rescue eyes with relapsed PIOL.
The researchers conducted a retrospective case series of patients having ocular relapse of PIOL who initially received systemic chemotherapy (all five cases) and external beam radiotherapy (EBRT) to brain and orbits (two cases). MTX injections (400 µg/0.1 mL) were given one time per week for 1 month, every other week for 4 months. This was followed by a maintenance phase of one injection one time per month for 8 months (total of 20 injections in a year).
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