OCT Biomarkers May Predict Retinal Atrophy Risk in nAMD Patients: Study

A new study published in the International Journal of Ophthalmology showed specific optical coherence tomography (OCT) features (type 2 macular neovascularization, reduced outer nuclear layer and central foveal thickness, and presence of intraretinal fluid) may be early indicators of increased risk for retinal atrophy in treatment-naïve patients with neovascular age-related macular degeneration.
Submacular fibrosis, photoreceptor shrinkage, and irreversible loss of central vision are all signs of advanced AMD. During the fundus oculi examination, retinal atrophy (RA) can be identified by the feature known as "geographic atrophy," which is the existence of delineated atrophic lesions of the outer retina brought on by the loss of photoreceptors, RPE, and choriocapillaris.
A noninvasive method for producing high-resolution cross-sectional pictures of the retina and underlying components is swept-source optical coherence tomography (SS-OCT). In order to predict retinal atrophy (RA) and visual function in patients receiving intravitreal aflibercept, this study was set to identify optical coherence tomography characteristics present at the diagnosis of neovascular age-related macular degeneration.
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