Oxymetazoline eye drops, a promising treatment for ptosis: JAMA

USA: Oxymetazoline, 0.1% may be a promising treatment for acquired ptosis, suggest a recent study in the journal JAMA Ophthalmology. This will do away with the need to undergo surgery for treating the condition.

Blepharoptosis (or ptosis) is drooping down of the upper eyelid margin with the eye in primary gaze. The eyelid disorder is broadly categorized as either congenital or acquired. Currently, the treatment of acquired blepharoptosis (ptosis) is currently limited to surgical intervention. Charles B. Slonim, University of South Florida Morsani College of Medicine, Tampa, and colleagues examined the efficacy and safety of oxymetazoline hydrochloride, 0.1%, ophthalmic solution (oxymetazoline, 0.1%) in participants with acquired ptosis.

It included participants 9 years and older with acquired ptosis and superior visual field deficit. The 2 studies were conducted across 16 and 27 sites in the United States. 

The study enrolled 304 participants (mean age 63.8 years; 73% were women) from May 2015 to April 2019. Overall, 97.5% of participants received oxymetazoline, 0.1%, and 97.0% (98 of 101) of participants receiving the vehicle completed the studies. Participants were randomized in the ratio 2:1 to receive oxymetazoline, 0.1%, or vehicle, self-administered as a single drop per eye, once daily, for 42 days.