Pentosan polysulfate sodium use related to retinal disorders: JAMA
Birmingham: A recent study published in the journal JAMA Ophthalmology has revealed an association between the use of pentosan polysulfate sodium (PPS) and an elevated risk of maculopathy.
Case series have suggested a link between PPS usage and a macular condition. However, observational studies seeking to quantify this association have given equivocal results. To clarify the same, Gerald McGwin Jr, the University of Alabama at Birmingham, Birmingham, and colleagues aimed to estimate the association between PPS exposure and maculopathy.
From January 2013 to June 2020, this disproportionality research was carried out utilizing the US Food and Drug Administration Adverse Event Reporting System. Adverse event records for pentosan polysulfate were chosen and compared to adverse event reports for medicines used to treat interstitial cystitis, cystitis, bladder problem, or bladder discomfort.
The retinal disorders Standardized Medical Dictionary for Regulatory Activities (MedDRA) Query was used to identify retinal adverse events, which include conditions associated with retinal damage caused by a blockage of its blood supply, nutritional deficiencies, toxins, and diseases affecting the retina.
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