Pregabalin during LASEK surgery reduces pain and affects corneal nerve sensitivity: BMJ
South Korea: In a new study conducted by Dong Won Paik and team it was seen that pregabalin may affect corneal nerve sensitivity and minimize discomfort during laser epithelial keratomileusis (LASEK) surgery. The findings of this study were published in the British Journal of Ophthalmology, on 22nd March 2022.
Dryness and soreness are hypothesized to be caused by corneal nerve injury during laser epithelial keratomileusis. As a result, the purpose of this study was to see if taking pregabalin (Lyrica), lowers peripheral neuropathic pain, improves corneal nerve sensitivity following surgery and decreases dry eye and pain.
Patients in this trial were given pregabalin (150 mg twice a day for 15 days) starting the day before surgery and were compared to individuals who did not get the drugs. The degree of dry eye was determined prior to surgery. The corneal sensitivity was then measured using esthesiometry, and pain was measured using the Visual Analogue Scale. Confocal microscopy was used to examine images of the sub-basal nerve plexus at 6 months to assess nerve regeneration.
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