Single intravitreal dose of bevacizumab during trabeculectomy with mitomycin-C improved surgical success

Trabeculectomy is a most popular surgery performed in glaucoma patients. Before the development of the trabeculectomy, the available surgical methods to treat intraocular pressure (IOP) reduction had a high rate of serious complications such as hypotony, flat anterior chamber, and endophthalmitis, however the surgery still needs validation on recovery.

A recent study reveals that bevacizumab was associated with a significant reduction in the need for additional medication or further surgery to achieve target IOP. Bevacizumab was also associated with larger blebs that were less inflamed and required fewer subsequent interventions. Bevacizumab given as a single intravitreal dose during trabeculectomy with mitomycin-C (MMC) resulted in improved surgical success as 12 months.

The researchers evaluated the efficacy and the effect of an intraoperative dose of intravitreal bevacizumab (Avastin) on surgical success following trabeculectomy with mitomycin-C (MMC) over 12 months. The findings are published in British Journal of Opthalmology.

The study was a single centre, parallel, double-blinded randomised, placebo-controlled trial recruiting patients requiring trabeculectomy for progressing glaucoma. Patients were randomised to intravitreal bevacizumab or placebo. The primary outcome of treatment success was defined by 'complete success' when intraocular pressure (IOP) remained less than a predefined target IOP without the requirement of topical medication, or 'qualified success' where topical medication was required to meet the predefined target IOP threshold. Secondary outcomes included the need for subsequent IOP-lowering interventions, and structural parameters associated with bleb function.