Statins may be used to treat primary open-angle glaucoma associated with lower ABCA1 expression
Glaucoma is an irreversible blinding eye disease characterized by progressive ganglion cell death. To date, IOP control has been almost the only clinical option for the treatment of POAG. However, visual field damage continues to progress after lowering IOP in most patients, suggesting the existence of more complex pathogenic mechanisms in glaucoma.
Recently, a collaboration between Academician Yang Zhenglin and Professor Zhang Houbin of Sichuan Provincial People's Hospital affiliated with the University of Electronic Science and Technology revealed the important role of cholesterol metabolic homeostasis in the pathogenesis of glaucoma and rescued the ganglion cells of ABCA1 knockout mice after lowering intracellular cholesterol with statin, which provides a new idea for the treatment of glaucoma.
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