Stem cell-based therapies novel strategy that may substitute conventional corneal transplantation
Major advances in medicine are currently being made in regenerative medicine for cornea. Stem cell-based therapies represent a novel strategy that may substitute conventional corneal transplantation, albeit there are many challenges ahead given the singularities of each cellular layer of the cornea.
A recent study in Science Advances aimed to treat unilateral limbal stem cell (LSC) deficiency, Ula V. Jurkunas and the team of researchers, developed cultivated autologous limbal epithelial cells (CALEC) using an innovative xenobiotic-free, serum-free, antibiotic-free, two-step manufacturing process for LSC isolation and expansion onto human amniotic membrane with rigorous quality control in a good manufacturing practices facility.
The current study if successful, will be the first to use of CALEC in the United States will serve as a steppingstone for establishing cellular therapy products as viable options for patients with LSCD.
The clinical hallmarks of LSC deficiency (LSCD) include conjunctivalization, neovascularization, recurrent or persistent epithelial defects, inflammation, and corneal scarring. These changes lead to loss of vision, pain, and impaired quality of life.
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