Study Links Semaglutide to Increased NAION Risk in Diabetes Patients
Taiwan: A recent cohort study published in JAMA Ophthalmology suggests that patients with diabetes who use semaglutide may face an increased risk of developing nonarteritic anterior ischemic optic neuropathy (NAION). However, researchers caution that the study's retrospective design limits its ability to establish a direct causal relationship, highlighting the need for further investigation.
Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA), is widely prescribed for managing type 2 diabetes and obesity. It offers well-documented benefits in glycemic control and weight reduction. However, emerging evidence raises concerns about its potential ocular side effects, particularly its association with nonarteritic anterior ischemic optic neuropathy, a condition characterized by sudden vision loss due to impaired blood flow to the optic nerve.
Recent studies have suggested a possible link between semaglutide use and NAION. However, given the limitations of these analyses, further research is needed to understand this association better, especially considering the widespread use of these medications in individuals with and without diabetes. Considering this, Alan Y. Hsu, Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan, and colleagues aimed to examine the potential link between semaglutide use and the risk of NAION in patients with diabetes.
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