Subconjunctival injection of triamcinolone acetonide may prevent complications after phacoemulsification: Study
In recent research conducted by Kaiser Permanente Northern California, a single injection of triamcinolone acetonide (TA) was identified to be more effective and safer than traditional topical prednisolone acetate (PA) in preventing complications following cataract surgery. The findings were published in the Ophthalmology journal.
This retrospective study spanned from 2018 to 2021 and included 69,832 patient-eyes which underwent phacoemulsification to remove cataract. The patients were categorized into groups receiving either topical PA with or without a nonsteroidal anti-inflammatory drug (NSAID) or a subconjunctival injection of TA, at varying doses and concentrations. The effectiveness of these treatments was evaluated based on the incidence of postoperative macular edema (ME) and iritis and the safety was assessed via the occurrence of glaucoma-related events within a year following the surgery.
The results highlighted that the high-dose TA (10 mg/mL) group showed a statistically significant reduction in the risk of developing postoperative ME when compared to the group treated with topical PA. The odds ratio (OR) was 0.64 which suggests a 36% lower risk and provides promising insight into the potential benefits of opting for an injection over topical solutions. Further, the combination of PA and NSAID did not show a statistically significant benefit in reducing ME.
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