Topical atropine and NSAIDs before cataract surgery may reduce IFIS risk

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2022-04-18 04:00 GMT | Update On 2022-04-18 11:29 GMT

Cataract Surgery

Israel: Preoperative administration of topical atropine 1% and non-steroidal anti-inflammatory drugs (NSAIDs) before cataract surgery may prevent intraoperative floppy iris syndrome (IFIS), says a recent study. The study appears in Graefe's Archive for Clinical and Experimental Ophthalmology.

The study was conducted by Margarita Safir, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, and colleagues with an objective to examine the efficacy of preoperative administration of topical atropine 1% and NSAIDs for the prevention of intraoperative floppy iris syndrome in a retrospective cohort study.

The study included patients who underwent cataract surgery by phacoemulsification between July 2019 and February 2020 in two hospitals in Israel having similar patient demographics and similar surgical techniques. However, they differ in policy of IFIS prevention.

In Meir Medical Center no preventive medications are given pre-operatively, while in Shamir Medical Center patients at risk for IFIS receive topical atropine 1% once daily and non-steroidal anti-inflammatory drugs (NSAIDs) thrice daily for 3 days preoperatively.

Overall, the study included 207 eyes of 207 patients with a history of alpha-antagonist use. Mean age was 74.9 ± 7.8 years and 82.1% (n = 170) were male.

The study revealed the following findings:

Among patients from the pretreating center, 86.8% (n = 92/106) were pre-treated with either NSAIDs or atropine preoperatively, while in the non-pretreating center no treatment was prescribed (n = 0/101).
IFIS rate among the non-pretreating center was 29.7% (n = 30/101) compared to 15.1% (n = 16/106) in the pretreating center.
When strictly comparing treated to untreated patients, the treated group had an IFIS rate of 12.0% compared to 30.4% among the untreated.
Adjusted for age and gender results remain consistent (odds ratio 0.329 for treated patients).

The findings led to the conclusion that IFIS rates were significantly lower in the pretreating center versus the non-pretreating center. Differences were even more pronounced when comparing strictly treated to untreated patients.

Reference:

Sharon, T., Hecht, I., Atar Vardi, M. et al. Preoperative atropine and non-steroidal anti-inflammatory drugs for the prevention of intraoperative floppy iris syndrome. Graefes Arch Clin Exp Ophthalmol 260, 893–900 (2022). https://doi.org/10.1007/s00417-021-05444-1

Article Source : Graefe's Archive for Clinical and Experimental Ophthalmology

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Medha Baranwal

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Topical atropine and NSAIDs before cataract surgery may reduce IFIS risk

Similar News

Machine Learning Flags Key Risks for Early Macular Degeneration: Hypertension, Joint Disorders, and Dyslipidemia: Study

OSA increases the risk of retinal vein occlusion in Hispanic/Latino population: Study

Danegaptide Advances to Phase 2 for Diabetic Retinopathy Treatment

Blinking Exercises Improve Dry Eye Symptoms and Eyelid Function: Study

Metabolic Syndrome Increases Cataract Risk, Especially in 50 + Individuals: Study

Aston University optometrist develops app with the best easy blinking exercises to improve dry eye symptoms

GLP-1 Receptor Agonists Promising in Managing Idiopathic Intracranial Hypertension: JAMA Study

Botulinum Toxin A Injections Show Significant Benefits in Dry Eye Disease: Study