Topical brimonidine 0.15% reduces conjunctival injection after strabismus surgery in kids
Conjunctival injection is one of the most common complications after strabismus surgery. Although patients do not expect conjunctival injection to persist for a long time after surgery, it may cause anxiety, cosmetic problems, and disappointment, despite successful ocular alignment.
Brimonidine tartrate is a selective α2-adrenergic receptor agonist that has been widely used to lower intraocular pressure (IOP). As brimonidine affects vasoconstriction primarily via the α2-adrenergic receptor, it has been reported that the pre- and postoperative use of topical brimonidine can help reduce bleeding-related problems in ophthalmic surgery. In addition, brimonidine has relatively lower systemic adverse effects than other vasoconstrictors such as phenylephrine, and the safety of brimonidine has been confirmed in children over 2 years of age.
Kim et al performed a study to evaluate the effect of brimonidine on conjunctival injection after strabismus surgery in children.
Authors retrospectively analyzed 63 Korean children who underwent strabismus surgery for intermittent exotropia. Patients received topical brimonidine 0.15% after surgery for up to 4 weeks. Conjunctival injection was objectively assessed using a software that automatically scored the region of interest from the image of the bulbar conjunctiva. Conjunctival injection scores were compared with those of the control group who were not prescribed topical brimonidine.
Source: Dong Hyun Kim ,Hee Kyung Yang ,Sang Beom Han and Jeong-Min Hwang; Hindawi Journal of Ophthalmology Volume 2021
DOI: https://doi.org/10.1155/2021/5574194
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