Tranexamic Acid Injection may Reduce Postoperative Bruising in Eyelid Surgery, reveals research

• A total of 130 patients participated in the study. Findings revealed significantly less eyelid ecchymosis on the tranexamic side at both postoperative day 0 (p = 0.001) and POW 1 (p < 0.001).

• Specifically, the 69 levator advancement surgeries showed markedly less ecchymosis at postoperative day 0 (p < 0.001) and POW 1 (p = 0.001).

• Upper eyelid blepharoplasty, combined upper and lower lid blepharoplasty, and conjunctivomullerectomy showed trends towards significance.

• Among 68 patients who reported their grading at POW 1, 69% noted less bruising on the tranexamic side (p < 0.001).

• No significant difference in intraoperative bleeding was observed between the sides (p = 0.930).

The study demonstrated that administering subcutaneous tranexamic acid without a waiting period before eyelid surgery significantly reduces postoperative bruising. This effect was evident on both postoperative day 0 and POW 1, particularly in levator advancement surgeries. The lack of significant difference in intraoperative bleeding suggests that the immediate initiation of surgery post-injection does not increase intraoperative risks.

Administering subcutaneous tranexamic acid without a waiting period before eyelid surgery effectively reduces postoperative bruising without affecting intraoperative bleeding. These findings suggest that a higher dose of tranexamic acid can be a promising intervention to improve surgical outcomes and patient satisfaction in eyelid surgery.

Reference:

Paramo, R., Cheng, T., Malik, A., Fan, J., & Barmettler, A. (2024). Effect of tranexamic acid on intra- and postoperative bleeding in eyelid surgery: A prospective, randomized, multicenter, double-masked, control trial. Ophthalmic Plastic and Reconstructive Surgery, 40(3), 331–335. https://doi.org/10.1097/iop.0000000000002583