Varenicline nasal spray may improve tear production in dry eye disease
Varenicline nasal spray effectively manages Dry Eye Disease and improves tear production and DED signs.
A recent study evaluating the efficacy of varenicline nasal spray (VNS) versus vehicle/placebo for treating dry eye disease has concluded that VNS use improves Schirmer test scores over 28 days of treatment.
They noted more incidence of cough and throat irritation in the VNS group.
The lead researcher of this study, “The efficacy and safety of varenicline nasal spray for the management of dry eye signs: a systematic review and meta-analysis”, is Dr Bader Bashrahil and is published in BMC Ophthalmology.
It is already known that the leading cause of DED is persistently unstable tear film causing ocular discomfort. This eye condition is treated using tear supplementation. Emerging evidence supports the effectiveness of nicotinic acetylcholine receptor (nAChR) agonists (e.g., varenicline and simpinicline) nasal sprays for managing DED.
In the present study, the team assessed the efficacy and safety of varenicline nasal spray (VNS) for DED treatment using databases like CENTRAL, Medline, and Embase.
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