Achilles Tendon Softness may help detect Familial hypercholesterolemia

In a recent study, researchers have reported that AT softness along with AT thickness (AT-T) helps to diagnose familial hypercholesterolemia. The research has been published in the JACC: Cardiovascular Imaging on March 31, 2021.

Despite being specific for FH, AT xanthomas may clinically be undetectable which may lead to under-diagnosis. To date, ultrasonography has been used to assess Achilles tendon thickness (ATT) to diagnose patients with familial hypercholesterolemia. Researchers hypothesized that the softness of the Achilles tendon might also be an important indicator of FH."We hope that Achilles tendon elastography may encourage clinicians to diagnose FH more correctly and actively," said author Masatsune Ogura, MD, PhD, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan, in an interview.

The researchers conducted this study to investigate whether combining measurement of AT softness and thickness improve the diagnostic accuracy of FH. The researchers measured AT elasticity with sonoelastography in 115 genetically diagnosed heterozygous FH patients and 77 non-FH control subjects.

The key findings of the study were:

• Upon analysis, the researchers noted that the Achilles tendon thickness was greater and its degree of softness, measured by the elasticity index, was lower in the genetically diagnosed FH group compared with the non-FH group, indicating that the AT of FH patients was thicker and softer than that of non-FH patients.
• They also observed an inverse relation between the elasticity index and Achilles tendon thickness only in FH patients, suggesting that the Achilles tendon of FH patients becomes softer as it becomes thicker.
• Upon receiver operating characteristic (ROC) analyses, they noted that the cutoff values of Achilles tendon softness to diagnose FH in women were 4.7 mm in both men and women.

Ogura said, "The combined use of the elasticity index cutoff value and those for Achilles tendon thickness improved the detection rate."

He further added, "We consider that measuring Achilles tendon softness in addition to the thickness may be beneficial for suspected FH patients whose Achilles tendon thickness is borderline or falls short of the cutoff value due to lipid-lowering treatment or younger age,".

For further information:

https://www.jacc.org/doi/full/10.1016/j.jcmg.2021.01.033