Anakinra an effective option for gout flares, Study says
According to recent study, it has been found out by the researchers from the Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, USA that Anakinra is an effective option for gout flares when conventional therapy is unsuitable.
The study is published in the Arthritis and Rheumatology Journal.
Gout is strongly associated with comorbidities, including obesity, metabolic syndrome, type II diabetes, hyperlipidemia, hypertension, chronic kidney disease (CKD), and coronary artery disease. Comorbidities frequently restrict conventional treatment options (ie, nonsteroidal anti-inflammatory drugs [NSAIDs], colchicine, corticosteroids) for gout flares. Acute gout flares are mediated by NLRP3 inflammasome activation with consequent interleukin-1β (IL-1β) release.
Anakinra was non-inferior to conventional approved therapies for acute gouty arthritis in a recent controlled trial. However, the interleukin-1 (IL-1) receptor antagonist anakinra is an effective, off-label option in acute gout flares, when conventional therapy options are narrowed.
Hence, Kenneth G. Saag and colleagues conducted the present study to evaluate anakinra efficacy and safety compared to triamcinolone in the treatment of gout flares.
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