Baricitinib Lowers Structural Joint Damage in Patients With RA: Study
Baricitinib helps to reduce structural joint damage in Patients With rheumatoid arthritis (RA), suggests a study published in the Journal of Rheumatology.
A group of researchers from the Netherlands conducted a study to evaluate the effect of baricitinib on inhibiting the radiographic progression of structural joint damage over 5 years in patients with active rheumatoid arthritis (RA). They stated, "Because no cure for RA exists, it is important to reduce a patient's inflammation to the lowest level possible to prevent structural damage from accruing and thereby maintaining patients' functional ability."
Patients completed 1 of 3 phase 3 baricitinib trials and entered the long-term extension RA-BEYOND, in which patients received once-daily 4 mg or 2 mg baricitinib. Across these trials, patients initially receiving methotrexate (MTX) or adalimumab switched to baricitinib 4 mg at week 52. Patients initially receiving placebo switched to baricitinib 4 mg at week 24. Radiographs were scored at baseline and years 2, 3, 4, and 5. Change from baseline in van der Heijde modified Total Sharp Score (ΔmTSS) was computed.
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