Brodalumab substantially improves symptoms in psoriatic arthritis, reports Study
Brodalumab is associated with rapid and significant improvements in signs and symptoms of PsA versus placebo. It also seems to be well tolerated, with a safety profile consistent with other interleukin-17 inhibitors, reported a recent study published in the Annals of the Rheumatic Diseases.
Current treatment guidelines for Psoriatic arthritis recommend biologic disease-modifying antirheumatic drugs (DMARDs) as a treatment option on the inadequate response following treatment with non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and conventional synthetic DMARDs. Despite the advent of therapeutics, an unmet need remains in PsA as a significant proportion of patients either do not respond or eventually lose response to currently available therapies.
However, Brodalumab 210mg is currently approved for the treatment of moderate-to-severe plaque psoriasis in the USA, EU, Canada, and certain Asian countries and for PsA currently only in Japan. The safety profile of brodalumab in PsA was consistent with the safety profile established in the psoriasis clinical trial program, and the clinical responses were sustained.
Therefore, to further evaluate the efficacy and safety of brodalumab in PsA, two double-blind, randomized, phase III trials, AMVISION-1 (NCT02029495) and AMVISION-2 (NCT02024646), was conducted. The primary objective of both trials was to compare the efficacy of brodalumab with placebo in patients with PsA. Both trials were placebo-controlled through week 24. Data at week 16 from individual trials and week 24 from a pooled analysis were observed, describes Philip J Mease and colleagues from the Rheumatology Research, Swedish Medical Center, Seattle, Washington, USA.
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