Diacerein noninferior to celecoxib for pain reduction in knee OA: Study
Canada: Diacerein is equally effective as celecoxib for reducing knee osteoarthritis (OA) pain and improving physical function, finds a recent study in the journal Rheumatology. Also, diacerein demonstrated a good safety profile.
Jean-Pierre Pelletier, University of Montréal Hospital Research Centre (CRCHUM), and colleagues compared the efficacy of diacerein versus celecoxib in pain reduction for the treatment of patients with symptomatic knee OA.
In the randomized double-blind multicentre non-inferiority trial, the researchers evaluated diacerein vs celecoxib treatment in patients with Kellgren–Lawrence grade 2–3 and pain scoring ≥4 (10-cm VAS). Patients were randomized to receive either 6 months of treatment with diacerein 50 mg (n = 187) once daily for 1 month and twice daily thereafter, or celecoxib 200 mg (n = 193) once daily.
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