Elevated Total Alkaline Phosphatase Levels linked to increased risk of Osteoporosis and Mortality: Study
Elevated levels of serum total alkaline phosphatase (T-ALP) have been linked with decreased bone mineral density (BMD), higher prevalence of osteoporosis, and higher mortality rate in patients with osteoporosis. This was concluded in a recent study published in the journal Osteoporosis International conducted by Ran Chen and colleagues.
Data were analyzed from 13,724 adults aged 18 to 85 years who had participated in National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. Mortality data were obtained from the National Death Index through December 31, 2019. Serum T-ALP levels were correlated with BMD at the femoral neck and lumbar spine using linear regression models, subgroup analysis, and weighted logistic regression. Of participants diagnosed with osteoporosis (n = 944), survival analysis, including Kaplan-Meier curves and Cox proportional hazards models, was applied to examine how serum T-ALP could predict mortality.
The study had a number of important findings:
• High serum T-ALP levels were correlated strongly with low BMD both at the femoral neck and the lumbar spine. In fact, this correlation was apparent across all subgroups which include age, sex, race, and BMI
Osteoporosis Prevalence :
• The prevalence of osteoporosis in each 1 SD increase for T-ALP values was increased by 0.5% [Odds Ratio (OR) : 1.005; 95% CI : 1.005–1.005 ; p < 0.001].
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