Guselkumab Shows Superior Efficacy Over Ustekinumab for treatment of Psoriatic Arthritis: Study
Psoriatic arthritis is a chronic inflammatory condition that affects joints and skin, often causing pain, swelling, and skin lesions. Biologic therapies like guselkumab and ustekinumab have shown promise in managing PsA, but direct comparisons of their efficacy remain scarce.
A recent study published in Rheumatology and Therapy provides compelling evidence regarding the efficacy of guselkumab compared to ustekinumab in the treatment of psoriatic arthritis (PsA). Using individual patient-level data (IPD) analysis, researchers aimed to elucidate the comparative effectiveness of these two biologic treatments, shedding light on their joint and skin efficacy over a 52-week period.
Researchers Thilakarathne P and colleagues conducted an IPD analysis, pooling data from the DISCOVER-1, DISCOVER-2, PSUMMIT-1, and PSUMMIT-2 trials, encompassing a total of 44,115 participants. The analysis focused on evaluating joint and skin efficacy outcomes, including American College of Rheumatology 20% improvement (ACR20) and Psoriasis Area Severity Index 90% reduction (PASI 90) response rates.
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