High blood leptin levels associated with chronic widespread pain in rheumatoid arthritis, finds study
High blood leptin levels are associated with chronic widespread pain in rheumatoid arthritis, according to a study published in Arthritis Research & Therapy.
High body mass index (BMI) has been shown to have an association with chronic widespread pain (CWP), both in Rheumatoid arthritis (RA) and in other pain conditions such as fibromyalgia. Research on the adipose tissue and it's adipokines, for example, the well-described leptin, is emerging. This study aimed to determine if there is an association between leptin levels in blood and CWP in patients with Rheumatoid arthritis.
In this cross-sectional study, 334 patients with Rheumatoid arthritis filled in a questionnaire including a pain mannequin and questions on weight, length and waist circumference. Data from the pain mannequin was used to calculate CWP. The subjects also submitted blood samples to a biobank that were used for this study to determine leptin levels using an ELISA method. Results: Patients fulfilling the 2019 criteria for CWP in this study had significantly higher leptin levels, waist circumferences and BMI.
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