Hyperuricemia independent risk factor for achilles tendon rupture in males: study

Key findings of the study were:

• Univariate logistic analysis showed that BMI, smoking, and hyperuricemia were risk factors for the development of ATR (OR=1.65, 95%CI 1.13–2.42, P=0.01; OR=1.47, 95%CI 1.00–2.24, P<0.05; OR=2.85, 95%CI 1.84–4.42, P<0.01).

• Multifactorial analysis showed that BMI≥25 kg/m2, smoking, and hyperuricemia were independent risk factors for the development of ATR (OR=1.66, 95%CI 1.11–2.49, P=0.01; OR=2.15, 95%CI 1.28–3.60, P<0.01; OR=3.06, 95%CI 1.92–4.89, P<0.01).

• Among the blood biochemical indicators, total cholesterol (TC) and uric acid (UA) were independent risk factors for the occurrence of ATR (OR=1.54, 95% CI 1.12–2.12, P=0.01; OR=1.01, 95% CI 1.01–1.01, P<0.01).

The authors concluded – “Our study confirmed that, as in previous results, higher BMI, smoking, and total cholesterol are risk factors for ATR, hyperuricemia may contribute to the development of ATR, and adjunctive tests for TC and UA in the blood biochemistry may be helpful in predicting the risk of ATR.”

Further reading:

Hyperuricemia as an independent risk factor for achilles tendon rupture in male: a case– control study Chen et al. Journal of Orthopaedic Surgery and Research (2024) 19:215 https://doi.org/10.1186/s13018-024-04698-9