Ibuprofen+Acetaminophen is no better than Ibuprofen alone for low back pain

Bronx, NY: Acetaminophen+Ibuprofen versus ibuprofen alone did not improve disability or pain one week after discharge in patients with acute low back pain (LBP), according to a recent study published in the journal Academic Emergency Medicine.

LBP patients are often treated with nonsteroidal anti‐inflammatory drugs (NSAIDs) which are modestly effective for LBP. But, many LBP patients continue to suffer despite treatment with these medications. Benjamin W. Friedman, Department of Emergency Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, and colleagues compared functional outcomes and pain, 1 week after discharge from the emergency department (ED) in LBP patients randomized to 1-week course of acetaminophen+ibuprofen versus ibuprofen+placebo. 

This randomized, double-blind study was conducted in two urban EDs. Patients presenting with acute, nontraumatic, nonradicular LBP of no more than 2 weeks' duration were eligible for enrollment immediately prior to discharge from an ED if they had a score > 5 on the Roland Morris Disability Questionnaire (RMDQ) -- a 24‐item validated instrument, indicating more than minimal functional impairment. All the 120 patients who met selection criteria and randomized were given a standardized 10‐minute LBP educational session prior to discharge.