Intra-articular calcium crystal deposition increases frequency and intensity of knee pain
In knee osteoarthritis (OA) cases, intra-articular (IA) calcium crystal deposition is common. A recent study published in Arthritis and Rheumatology has demonstrated a two-times higher likelihood of frequent knee pain and more intermittent or constant pain in patients with intra-articular mineralization.
Low-grade, crystal-related inflammation may contribute to knee pain. In the present study, researchers examined the longitudinal relation of CT-detected IA mineralization to the development of knee pain using data from the NIH-funded longitudinal Multicenter Osteoarthritis (MOST) Study.
At baseline, participants had knee radiographs and bilateral knee CTs. For two years, for every eight months, a pain assessment was done. CT images were scored using the Boston University Calcium Knee Score (BUCKS). They used generalized linear mixed-effects models to examine CT-detected IA mineralization in relation to the risk of frequent knee pain (FKP)/intermittent/constant knee pain worsening and pain severity worsening.
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