JAK Inhibitors Linked to Higher Cancer Risk in RA Patients: Study
Data from a large German registry has revealed that Janus kinase (JAK) inhibitors used for rheumatoid arthritis are associated with significantly higher rates of malignancies compared to biologic agents. While some earlier studies showed mixed results, this study confirmed increased cancer risk overall, particularly in certain patient subgroups. The findings of the study have been published in the journal Annals of the Rheumatic diseases.
A study was done to estimate the effects of Janus kinase inhibitors (JAKis) vs biologic disease-modifying antirheumatic drugs (bDMARDs) on the risk of incident malignancies (excluding nonmelanoma skin cancer) in patients and patient subgroups with rheumatoid arthritis.
Episodes of disease-modifying antirheumatic drug (DMARD) treatment initiated between January 2017 and December 2020 and followed up to June 2024 in RABBIT, the German register for the long-term observation of therapy with biologics and targeted disease-modifying antirheumatic drugs in adult patients with rheumatoid arthritis, were analysed. Incidence rates (IRs) per 1000 patient-years with 95% CIs were calculated, and incident malignancy risk was estimated as hazard ratios (HRs) by inverse probability weighted adjusted Cox models.
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