Pelvic bone loss may contribute to pelvic stress fracture after hip replacement surgery

Although several risk factors for SIF have been identified, the role of THA is unclear. Dr. Graul and colleagues designed a two-part study to assess the influence of THA on the development and localization of SIF. In a review of 171 patients diagnosed with SIF, the researchers identified 50 patients with previous THA in one or both hips. The average age was 79 years, and 40 of the patients were women. On average, SIF developed about eight years after THA.

Among the 31 SIF patients who had undergone THA in just one hip, the SIF was located in the opposite side twice as often as in the operative side (42 percent compared with 19 percent, respectively). The remaining 39 percent of patients developed SIF on both sides of the pelvis.

In the second part of the study, the researchers analyzed 39 patients with initially healthy bone mineral density who underwent THA. Changes in bone density were assessed in computed tomography scans performed at 1 year after THA. The results showed a small but significant reduction of bone mineral density in the sacrum, but only on the side opposite from the THA. There was no significant change in bone mineral density in the sacrum on the same side as the THA.

Over time, THA may lead to "spatially different bone remodeling," as a result of changes in load transmission through the pelvis, Dr. Graul and colleagues write. The authors note that a key question remains unresolved: does THA cause decreased bone loss on the opposite side of the sacrum, or does it prevent bone loss on the same side of the sacrum. The researchers conclude, "additional studies focusing on this remodeling process, and assessing different implant designs and longer-term changes, are needed."