Pulsed low-intensity ultrasonography may not reduce symptoms or cartilage loss in knee osteoarthritis
USA: In a new study, it was found that the use of pulsed low-intensity ultrasonography (PLIUS) showed no clinical improvement or reduction in tibiofemoral cartilage thickness loss in knee osteoarthritis (OA). The findings of this study were published in the JAMA Network Open.
There are no licensed therapies to halt the progression of osteoarthritis in the United States, but animal studies show that pulsed low-intensity ultrasonography (PLIUS) may encourage cartilage regeneration. Allen D. Sawitzke and colleagues conducted this research to investigate the efficacy of PLIUS in providing symptom relief and reduced loss of tibiofemoral cartilage thickness in individuals with knee OA.
From May 22, 2015, through January 31, 2019, a phase 2A, parallel, sham-controlled, double-blind randomized clinical study was undertaken at two Veterans Affairs hospitals in Salt Lake City, Utah, and San Diego, California. Data was evaluated between June 27, 2020, and October 20, 2020. Participants (N = 132) recruited through the US Department of Veterans Affairs with clinical and radiographic indications of early knee OA were randomly allocated to either PLIUS or a dummy device, which was self-administered for 20 minutes daily across the medial compartment of the knee. A 4-week pre-randomization sham run-in phase was followed by a 48-week treatment term for all registrants. Participants were randomly assigned to either PLIUS or sham ultrasonography for 48 weeks. The trial included two co-primary outcomes: clinical improvement as measured by Outcome Measures in Rheumatology cartilage preservation and Clinical Trials as measured by magnetic resonance imaging change in central medial femoral condyle cartilage thickness.
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