Risedronate associated with slightly higher risk of hip fracture during drug holiday compared with alendronate
Written By : Hina Zahid
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2022-03-07 03:30 GMT | Update On 2022-03-07 03:31 GMT
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A cohort study found that patients on a drug holiday after 3 or more years of taking risedronate were at slightly higher risk for hip fractures than patients taking a drug holiday from alendronate. However, overall risk of hip fracture during a drug holiday was low in both groups. The findings are published in Annals of Internal Medicine.
Risedronate and alendronate are common oral bisphosphonates prescribed to patients with osteoporosis. These bisphosphonates bind to bone and continue to affect bone turnover for extended periods, even after therapy discontinuation. Current guidelines recommend stopping these medications after 3 to 5 years due to both the strength of these bisphosphonate bonds and possible adverse events.
https://www.acpjournals.org/doi/10.7326/M21-2512
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