Sarilumab improves blood sugar in patients with RA with Diabetes: Study
Researchers have found in a post-hoc analysis that treatment with interleukin (IL)-6 receptor inhibitor sarilumab is associated with a greater improvement in glycemic control than conventional DMARDs or adalimumab among patients with comorbid rheumatoid arthritis (RA) and diabetes.
This reduction in blood sugar and glycosylated hemoglobin is seen among patients without Diabetes also. The findings of research have been published in the Arthritis Research & Therapy.
Oral glucocorticoids increase the risk for diabetes in patients with RA because of the adverse metabolic actions of these drugs, with a higher dose and longer treatment duration increasing the risk. Medical management of T2D and RA can be complicated by the potential effects of RA treatments on blood sugar levels.
The authors conducted a post hoc analysis of three-phase 3 studies to compare the effects of the IL-6 inhibitor sarilumab (Kevzara; Regeneron, Sanofi) to TNF inhibitors on glycosylated hemoglobin (HbA1c) among patients with RA, with or without diabetes. According to them, two of the studies were placebo-controlled trials of subcutaneous sarilumab administered in doses of 150 or 200mg once every 2 weeks, plus methotrexate, or conventional synthetic DMARDs. The third study was a monotherapy trial of sarilumab in doses of 200 mg every 2 weeks, compared with 40 mg of adalimumab.
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