Shorter antimicrobial prophylaxis good enough after clean orthopaedic surgery: JAMA
The use of a shorter antimicrobial prophylaxis duration and a lower antibiotic load is effective in clean orthopaedic surgery, according to a recent study published in the JAMA Network Open.
Postoperative healthcare-associated infections are associated with a greater deterioration in patients' general health status and social and economic burden, with at least 1 occurring in approximately 4% of acute care hospital patients. Antimicrobial prophylaxis prevents surgical site infections in various orthopaedic procedures; however, its relationship with health care-associated infections remains unknown.
A study was conducted to examine whether a shorter antimicrobial prophylaxis duration of fewer than 24 hours after surgery is not inferior to a longer duration in preventing health care-associated infections after clean orthopaedic surgery.
This open-label, multicenter, cluster-randomized, noninferiority clinical trial was conducted in 5 tertiary referral hospitals in the greater Tokyo metropolitan area, Japan, from May to December 2018. Adult patients undergoing clean orthopaedic surgery were recruited until the planned number of participants was achieved (500 participants per group). Statistical analysis was conducted from July to December 2019. Antimicrobial prophylaxis was discontinued within 24 hours after surgery in group 24 and 24 to 48 hours after surgery in group 48. Group allocation was switched every 2 or 4 months according to the facility-based cluster rule. Study-group assignments were masked from participants. The primary outcome was the incidence of health care-associated infections requiring antibiotic therapies within 30 days after surgery. The noninferiority margin was 4%.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.